Alexander Isak netted the lone strike of the game in the 12th minute as he headed a brilliant cross from Anthony Gordon past David Raya to give the Magpies all points on offer.
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In a statement, Genoa confirmed earlier reports that the match would be played without fans due to widespread clashes between the two clubs' hardcore ultras before and after Wednesday's derby,
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Ahead of Chelsea's trip to London rivals West Ham on Saturday, Maresca backed the 23-year-old Senegalese striker to be his side's number nine.